I’d keep the responsibility connected to spaces rather than asking full-backs to follow the same opponent everywhere.
When the wingers swap, the full-back should defend whoever enters their side unless there is a clear reason for a temporary handover.
The wide midfielder can help communicate the rotation, especially if one winger comes inside and another holds width.
If your full-backs start following opponents across the pitch, the back four quickly loses its normal distances.
I’d train against two wide attackers who are encouraged to swap repeatedly.
The defenders score by keeping the unit compact and passing responsibility cleanly rather than tracking a shirt.
At adult level, the players should understand that opponent rotations are designed partly to create confusion.
Do not solve the movement by creating more movement in your own defence.
Keep your reference points, communicate early, and only follow beyond your normal area when the immediate threat genuinely demands it.